Summary
This article explores Round Peg’s role in developing a bespoke lab enclosure for DNA synthesis, addressing the limitations found in off-the-shelf options. In response to Evonetix needs, Round Peg took charge of the entire development and build process, focusing on incorporating user requirements into the design.
The outcome was the successful delivery of multiple enclosures to Evonetix, significantly expanding their testing and DNA synthesis capability.
Introduction
Established in 2015, Evonetix has swiftly become a leader in synthetic biology arena, championing parallel DNA synthesis on silicon arrays. The evolution of Evonetix has seen the expansion of its suite of prototype instruments, which led to more complex test platforms that allowed a broader range of experimentation and closer test control.
The increasing complexity of these test platforms highlighted that existing off-the-shelf lab enclosures were unsuitable and unwieldy. Leveraging Round Peg’s longstanding partnership with their engineering team, Evonetix challenged them with designing a versatile custom enclosure that allowed for broad experimentation.
Design and Implementation
Recognising the importance of user interaction with the enclosure, Round Peg engineers worked closely with Evonetix scientists to capture their needs and expectations in a user requirement specification (URS). Key product success criteria were identified including the ability for continuous upgrades, easy maintenance, good all-round access and easy relocation.
During the design phase, key design features were incorporated to address these requirements. A lightweight, corrosion resistant, modular solution was created using aluminium extrusion frame. Additional features comprised of a spill-containment drip tray, a sizable retractable window for fume control and easy access and a custom 96-inch rack for control boards.
Round Peg also managed the supply chain and construction of the initial units, providing a full turn-key solution for Evonetix.
Conclusion
The custom enclosures proved to be a functional workhorse, allowing Evonetix to quickly expand their testing and DNA synthesis capacity. Beyond addressing the immediate housing needs, the enclosure allowed for 360-degree access, making it easier for scientists to operate and increasing throughput.
Evonetix now has six enclosures on-site, utilizing the modular enclosure design to further enhance their DNA synthesis capabilities.
Sophie Sladen, Head of Mechanical Engineering at Evonetix, said:
“Round Peg have been great to work with. They bring practical expertise and a strong understanding of the requirements for biotechnology applications. Their knowledgeable and flexible approach made them a highly valued partner and helped us progress our development work quickly and smoothly.”